Wolfgang H. Dillmann, MD

Wolfgang Dillmann, MD

Helen M. Ranney Distinguished Professor
Chair, Department of Medicine

Office Address:
9500 Gilman Drive # 0671
La Jolla, CA 92093-0671
wdillmann@ucsd.edu
Office: 858-822-3345
Fax: 858-822-3344

Education and Training

MD University of Munich School of Medicine 1970
Internship City Hospital Center, Elmhurst, Mt. Sinai Hospital, New York City 1970-1971
Residency Montefiore Hospital, Albert Einstein College of Medicine, New York 1971-1972
Fellowship Endocrinology and Metabolism, Montefiore Hospital
Albert Einstein College of Medicine, New York
1972-1975

Biography

Dr. Dillmann obtained his MD from the University of Munich in 1970 and completed his internship at Mt. Sinai Hospital in New York in 1971. At Montefiore, New York, Dr. Dillmann completed his medical residency in 1972 and his endocrinology fellowship in 1975. He accepted a position as Assistant Professor of Medicine, Albert Einstein College of Medicine, New York and moved to the University of Minnesota, Minneapolis, from 1976-1978.

Dr. Dillmann joined the UC San Diego faculty in 1979, becoming associate professor of medicine in 1981 and professor of medicine in 1987. From 2005 to 2010, he served as chief of the Division of Endocrinology and Metabolism. He took on the role of interim chair of the Department of Medicine upon Dr. Ken Kaushansky's departure in 2010. He was appointed Helen M. Ranney Professor and chair of the department in January of 2012 and is now Helen M. Ranney Distinguished Professor and Chair.

Research Interests

Dr. Dillmann has been involved in research for over 30 years. His current research centers on influences of endocrine diseases on cardiac function, especially thyroid hormone action and diabetes, basic mechanisms leading to congestive heart failure and the protection against ischemic injury.

Recent Publications

Belke DD, Swanson EA, Scott B, Stenbit A, Dillmann WH. Increased expression of SERCA in the hearts of transgenic mice results in increased oxidation of glucose. Am J Physiol Heart Circ Physiol 2007 292:H1755-H1763

Belke DD, Gloss B, Swanson EA, Dillmann WH. AAV-mediated expression of thyroid hormone receptor isoforms {alpha} 1 and {beta} 1 improves contractile function in pressure overload-induced cardiac hypertrophy. Endocrinology. 2007.148:2870-2877.

Llagostera E, Catalucci D, Marti L, Liesa M, Camps M, Ciaraldi TP, Kondo R, Reddy S, Dillmann WH, Palacin M, Zorzano A, Ruiz-Lozano P, Gomis R, Kaliman P. Role of myotonic dystrophy protein kinase (DMPK) in glucose homeostasis and muscle insulin action. PLoS ONE. 2007.2:e1134

Broderick KE, Alvarez L, Balasubramanian M, Belke DD, Makino A, Chan A, Woods VL Jr, Dillmann WH, Sharma VS, Pilz RB, Bigby TD, Boss GR. Nitrosyl-cobinamide, a new and direct nitric oxide releasing drug effective in vivo. Exp Biol Med 2007 232:1432-1440

Williamson CL, Dabkowski ER, Dillmann WH, Hollander JM. Mitochondria protection from hypoxia/reoxygenation injury with mitochondria heat shock protein 70 overexpression. Am J Physiol Heart Circ Physiol 2008 294: H249-H256

Xu M, Platoshyn O, Makino A, Dillmann WH, Akassoglou K, Remillard CV, Yuan JX. Characterization of agonist-induced vasoconstriction in mouse pulmonary artery. Am J Physiol Heart Circ Physiol 2008 294:H220- H228

Ngoh GA, Watson LJ, Facundo HT, Dillmann W, Jones SP. Non-canonical glycosyltransferase modulates post-hypoxic cardiac myocyte death and mitochondrial permeability transition. J Mol Cell Cardiol 2008 45(2):313- 25

Makino A, Platoshyn O, Suarez J, Yuan JX, Dillmann WH. Downregulation of connexin40 is associated with coronary endothelial cell dysfunction in streptozotocin-induced diabetic mice. Am J Physiol Cell Physiol 2008 295(1):C221-30

Rouf R, Greytak S, Wooten EC, Wu J, Boltax J, Picard M. Svensson EC, Dillmann WH, Patten RD, Huggins GS. Increased FOG-2 in Failing Myocardium Disrupts Thyroid Hormone-Dependent SERCA2 Gene Transcription. Circ Res 2008 103(5):493-501

Taleb M, Brandon CS, Lee FS, Lomax MI, Dillmann WH, Cunningham LL. Hsp70 Inhibits Aminoglycoside-Induced Hair Cell Death and is Necessary for the Protective Effect of Heat Shock. J Assoc Res Otolaryngol 2008 9(3):277-89

Xu M, Remillard CV, Sachs BD, Makino A, Platoshyn O, Yao W, Dillmann WH. p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction. Am J Physiol Heart Circ Physiol 2008 295(4):H1529-38

Suarez J, Scott B, Dillmann WH. Conditional increase in SERCA2a protein is able to reverse contractile dysfunction and abnormal calcium flux in established diabetic cardiomyopathy. Am J Physiol Integr Comp Physiol 2008 295(5):R1439-45

Romero-Perez D, Fricovsky E, Yamasaki KG, Griffin M, Barraza-Hidalgo M, Dillmann W, Villarreal F. Cardiac uptake of minocycline and mechanisms for in vivo cardioprotection. J Am Coll Cardiol 2008 52(13):1086-94

Hu Y, Suarez J, Fricovsky E, Wang H, Scott BT, Trauger SA, Han W, Hu Y, Oyeleye MO, Dillmann WH. Increased enzymatic O-GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose. J Biol Chem 2009 284(1):547-55

Ngoh GA, Facundo HT, Hamid T, Dillmann W, Zachara NE, Jones SP. Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia/reoxygenation injury. Circ Res 2009 104(1):41-9

Suarez J, Hu Y, Makino A, Fricovsky E, Wang H, Dillmann WH. Alterations in mitochondrial function and cytosolic calcium induced by hyperglycemia are restored by mitochondrial transcription factor A in cardiomyocytes. Am J Physiol Cell Physiol 2009 295(6):C1561-8

Makino A, Suarez J, Wang H, Belke DD, Scott BT, Dillmann WH. Thyroid Hormone Receptor {beta} is Associated with Coronary Angiogenesis during Pathological Cardiac Hypertrophy. Endocrinology 2009 150(4):2008-15

Dillmann W. Cardiac hypertrophy and thyroid hormone signaling. Heart Fail Rev 2009 12:125-132

Taleb B, Brandon CS, Lee FS, Harris KC, Dillmann WH, Cunningham LL. Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death. Cell Stress Chaperones 2009 14(4):427-37

Hilal-Dandan R, He H, Martin JL, Brunton LL, Dillmann WH. Endothelin Downnregulates SERCA2 Gene and Protein Expression in Adult Rat Ventricular Myocytes: Regulation by Pertussis Toxin-Sensitive Gi Protein and cAMP. Am J Physiol Heart Circ Physiol 2009 296(3):H728-34

de Zoeten EF, Wang L, Sai H, Dillmann WH, Hancock WW Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice. Gastroenterology 2010 138(2):583-94

Makino A, Scott BT, Dillmann WH. Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes. Diabetologia. 2010;53(8):1783-94.

Kayani AC, Close GL, Dillmann WH, Mestril R, Jackson MJ, McArdle A. Overexpression of HSP10 in skeletal muscle of transgenic mice prevents the age-related fall in maximum tetanic force generation and muscle Cross-Sectional Area. Am J Physiol Regul Integr Comp Physiol. 2010;299(1):R268-76.