Research Focus Areas

Molecular mechanisms of aging; impact of inflammation on the brain; chronic diseases of aging.

• Division of Geriatrics
• Stein Institute for Research on Aging

Molecular and cell biology of allergy; immune-mediated and inflammatory diseases; mucosal immunity.

• Clinical Trials: Center for Innovative Therapy
• Division of Rheumatology, Allergy and Immunology

• Division of Rheumatology, Allergy & Immunology
  • Bruce Zuraw, MD, chief of the division and inaugural holder of the US Hereditary Angioedema Association (HAEA) Endowed Chair and director of the first U.S. HAEA Angioedema Center at UC San Diego Health. 

Pathogenesis and treatment.

• Center for Innovative Therapy
• Division of Rheumatology, Allergy and Immunology

• Clinical Trials Center
• Division of General Internal Medicine
• Division of Physiology
• Division of Pulmonary, Critical Care & Sleep Medicine
  • Alpha 1-Antitrypsin Deficiency - UC San Diego is an Alpha-1 Foundation Clinical Resource Center
• Division of Rheumatology, Allergy and Immunology

• Division of Cardiology
• Division of Endocrinology and Metabolism
• UC San Diego Health: Open Clinical Trials 

• Dr. Shu Chien
• Division of Medical Genetics
  • Trey Ideker, PhD
    

• Institute of Engineering in Medicine
  • Ju Chen, PhD
  • Shu Chien, MD

Bioinformatics; clinical informatics; global health informatics and telemedicine; infrastructure, privacy technology and health information exchange.

• Division of Biomedical Informatics - current research projects

Core bioinformatics expertise to manage and analyze large molecular datasets, especially from next-generation sequencing. Special emphasis in genomics, systems biology and personalized medicine.

• Center for Computational Biology and Bioinformatics (CCBB)
• Division of Medical Genetics
  • Dr. Jill Mesirov

Atherosclerosis; cardiac electrophysiology; cardiac mechanics; heart failure; integrins in inflammation; interventional cardiology; molecular cardiology; physiology and pharmacology.

• Division of Cardiovascular Medicine
  • Research Activities
  • UC San Diego Health: Open Clinical Trials in Cardiovascular Diseases

• Center for Innovative Therapy
• Clinical and Translational Research Institute - Studies Recruiting Volunteers
• Clinical Trials Office at the Moores Cancer Center

• Division of Geriatrics
• UC San Diego/Salk Center for Academic Research and Training in Anthropogeny (CARTA)

Etiology, treatment, and prevention; molecular mechanisms; pathogenesis of diabetic kidney disease; the contribution of the kidney to cardiovascular disease in diabetes and obesity.

• Institute for Diabetes and Metabolic Health
  • Center for Clinical Diabetes Care
  • Center for Type 1 Diabetes Research
  • Center for Human Nutrition
  • Center for Integrative and Molecular Metabolism
• Division of Endocrinology and Metabolism
  • Research and Clinical Trials
• Division of Nephrology-Hypertension
  • Novel Paradigms in Diabetic Complications (NIH Type 1 Diabetes Targeted Research Award) 
• Center for Metabolic Research, VA San Diego Healthcare System
• Glycemic control in inpatients
• Division of Hospital Medicine
• Sanford Stem Cell Clinical Center
  • Clinical Trials

Celiac disease; gastrointestinal infection; intestinal inflammatory disease.

• Division of Gastroenterology
  • Gastroenterology Training Grant
  • Research and Clinical Trials
• Endoscopic Research
  
  • Colon cancer screening quality improvement
  • Pancreatic cancer diagnosis and prevention
  • New endoscopic devices
  • Natural orifice translumenal endoscopic surgery (NOTES)
  • Small intestinal imaging
  • Endoscopic treatment of early esophageal cancer

Obesity; lipid research; pituitary; thyroid; signal transduction; transcription; calcium and bone; reproductive endocrine diseases.

• Division of Endocrinology and Metabolism
  • Research and Clinical Trials
  • Fellowship Training

• Division of Medical Genetics
• Division of Regenerative Medicine

Molecular mechanisms of aging; impact of inflammation on the brain.

• Division of Geriatrics

HIV/AIDS, malaria, tuberculosis; risk factors, transmission, treatment, prevention, border health, health care utilization, STDs, viral hepatitis, substance use, migration and health, and social justice.

• Division of Biomedical Informatics - Active research projects
• Division of Infectious Diseases & Global Public Health - Active research projects

Division of Cardiovascular Medicine

• Advanced Heart Failure Fellowship Training Program
• Research

Experimental therapeutics; hematological malignancies; chronic lymphocytic leukemia; stem cell biology; tumor biology/immunology; hematopoiesis; platelet-vascular biology.

• Divisions of Hematology-Oncology and Bone Marrow Transplantation
• Sanford Stem Cell Clinical Center
  • Clinical Trials
• UC San Diego Health
  • Find a Clinical Trial
• UC San Diego Moores Cancer Center
  • Clinical Trials
  • Research Training

Pathogenesis, prevention, risk factors, transmission, treatment.

• AIDS Research Institute
  • HIV research, bioinformatics and information technologies - Douglas D. Richman, MD, Director, AIDS Research Institute
• Antiviral Research Center
  • UCSD Department of Medicine HIV/AIDS Clinical Trials Unit (NIH Cooperative Agreement)
• Center for AIDS Research (NIH Research Center Core Grant)
• Division of Infectious Diseases & Global Public Health
  • Training Program in Substance Use, HIV and Related Infections (NIH Training Grant)
  • Active Projects 

Glycemic control, venous thromboembolism prevention, transitions of care.

• Division of Hospital Medicine
  • Innovations Reducing Hyper- and Hypoglycemic Events in Inpatients (NIH Research Demonstration/Dissemination Project)

HIV and opportunistic infections; drug resistance; hepatitis B and C; Leptospira; malaria; tuberculosis; microbial pathogenesis; international medicine; neurovirology; prevention; tropical medicine; parasitology.

• Division of Gastroenterology
• Division of Infectious Diseases & Global Public Health
  • Research Activities
  • Dr. Robert Schooley
  • Dr. Davey Smith
    
• HIV Neurobehavioral Research Center
• Division of Pulmonary, Critical Care and Sleep Medicine

See Also HIV/AIDS

Developing new biotechnology therapies; conducting multicenter clinical trials; clinical pharmacology of medications used in treatment.

• Division of Gastroenterology

See Also Digestive Diseases

Development; physiology and pathophysiology; hypertension; immuno-pathogenesis and transplantation; function in early diabetes and diabetic nephropathy; acute injury and outcomes research; failure.

• Division of Nephrology-Hypertension
  • Acute Kidney Injury Research
    • Ravi Mehta, MD, FACP
  • Diabetic Kidney Disease
    • Kumar Sharma, MD, FAHA

Cancer clinical trials, cellular-immunotherapy, diagnostics, experimental therapeutics, gene immunotherapy, regenerative medicine, stem cell medicine, tumor biology.

• Clinical Trials
  • CIRM Alpha Stem Clinic at UC San Diego Health
  • Sanford Stem Cell Clinical Center Clinical Trials
    

• Divisions of Hematology-Oncology and Bone Marrow Transplantation
  • Januario E. Castro, MD
  • Catriona Jamieson, PhD, MD
  • Thomas J. Kipps, MD, PhD

• Division of Regenerative Medicine
  • Catriona Jamieson, PhD, MD

• Division of Endocrinology and Metabolism
• LIPID Metabolites And Pathways Strategy (LIPID MAPS) Consortium

Epidemiology and biomarkers for liver disease; multi-targeted therapies for liver cancer; molecular pathogenesis of fibrotic liver disease and the genetic basis of liver disorders;
progression of chronic liver diseases; hepatic fibrosis; alcoholic liver disease; liver failure; hepatitis B and C; clinical trials; treatments; transplantation; population screening; vaccination.

• Division of Gastroenterology
  • Research
    • Microbiome as Therapeutic Target in Alcoholic Hepatitis (NIH Cooperative Agreement)
      
    • Dr. Samuel Ho
    • Rohit Loomba Lab
      
    • Liver Epidemiology Fellowship
    • Transplant Hepatology Fellowship
• Division of Infectious Diseases & Global Public Health

Genomics and personalized medicine; systems biology.

Division of Medical Genetics ​​

• Trey Ideker, PhD
  • NDEx - The Network Data Exchange, A Network Commons for Biologists
  • A Systems Approach to Mapping the DNA Damage Response
  • Cytoscape, A Modeling Platform for Biomolecular Networks
  • Comparative Analysis of Genetic Interaction Networks
  • National Resource for Network Biology
  • San Diego Center for Systems Biology: From Maps to Models
  • Systems Biology and Integrative Networks Core, Chronic HIV Infection and Aging in NeuroAIDS (CHAIN) Center
• Jill Mesirov, PhD
  • GenomeSpace data analysis platform
• Network Approaches to Identify Cancer Drivers from High-Dimensional Tumor Data (NIH Early Independence Award to Hannah Carter, PhD)
• Training Program in Basic and Clinical Genetics (NIH Training Grant)

• NAFLD Research Center led by Rohit Loomba, MD, MHSc, Division of Gastroenterology and Hepatology

• Division of Endocrinology and Metabolism
• Division of Gastroenterology
• Division of Nephrology-Hypertension

• Division of Hematology-Oncology and Bone Marrow Transplantation 
• Moores Cancer Center
• Ongoing clinical trials

• UC San Diego Health Researchers Join Pancreatic Cancer "Dream Team" - Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences; Department of Medicine and Department of Surgery; Moores Cancer Center
• Division of Gastroenterology and Hepatology

COPD; drug-resistant tuberculosis; pulmonary function during weightlessness; respiratory biology; sleep medicine.

• Division of Pulmonary, Critical Care and Sleep Medicine
• NASA Laboratory studies
• Division of Hospital Medicine

• Moores Cancer Center
• Division of Regenerative Medicine
• Sanford Stem Cell Clinical Center and Sanford Consortium for Regenerative Medicine

Biology of immunologic and inflammatory diseases; pathogenesis and treatment of rheumatoid arthritis.

• Center for Innovative Therapy
• Division of Rheumatology, Allergy and Immunology
  • Rheumatic Diseases Research Training Grant (NIH Training Grant)

The pathogenesis of sleep apnea; metabolic/cardiovascular complications of sleep disorders; mechanical ventilation in acute respiratory distress syndrome.

Division of Pulmonary, Critical Care & Sleep Medicine

• Jess Mandel, MD

• Division of Biomedical Informatics
• Division of Medical Genetics

• Drug Resistance
  • Division of Infectious Diseases & Global Public Health
  • Division of Pulmonary, Critical Care & Sleep Medicine

Deep vein thrombosis; chronic thrombotic venous disease.

• Division of Pulmonary, Critical Care and Sleep Medicine
• Division of Rheumatology, Allergy, and Immunology

DVT prevention in inpatients:

• Division of Hospital Medicine